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KMID : 1146120210050010034
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Journal of Mucopolysaccharidosis and Rare Diseases
2021 Volume.5 No. 1 p.34 ~ p.38
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Growth Hormone Therapy in Children with Prader-Willi Syndrome
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Im Min-Ji
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Abstract
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Prader-Willi syndrome is a complicated genetic disorder caused by a mutation on chromosome 15q11-13. The disease results in morbid obesity due to hyperphagia, growth disturbance, multiple endocrine problems from hypopituitarism, developmental delay, and cognitive or behavioral problems. Recombinant human growth hormone has been used to improve body composition and muscle mass, which plays a main role in treating patients with Prader-Willi syndrome. We describe previous studies showing the efficacy and safety of growth hormone treatment in children with Prader-Willi syndrome and provide treatment guidelines. Growth hormone therapy could be beneficial for children with Prader-Willi syndrome and improve their quality of life.
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KEYWORD
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Prader-Willi syndrome, Growth hormone, Growth hormone deficiency, Guideline
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